TY - JOUR
T1 - Association Between Epicardial Adipose Tissue and Stroke
AU - Rosa, Maria Inês
AU - Grande, Antonio José
AU - Lima, Leticia Dorsa
AU - Dondossola, Eduardo Ronconi
AU - Uggioni, Maria Laura Rodrigues
AU - Hernandez, Adrian V.
AU - Tse, Gary
AU - Liu, Tong
AU - Pontes-Neto, Octávio Marques
AU - Biondi-Zoccai, Giuseppe
AU - Neto, Mansueto Gomes
AU - Durães, André Rodrigues
AU - Sá, Michel Pompeu B.O.
AU - Resende, Elmiro Santos
AU - Roever, Leonardo
N1 - Publisher Copyright:
Copyright © 2021 Rosa, Grande, Lima, Dondossola, Uggioni, Hernandez, Tse, Liu, Pontes-Neto, Biondi-Zoccai, Neto, Durães, Sá, Resende and Roever.
PY - 2021
Y1 - 2021
N2 - Epicardial adipose tissue (EAT) is correlated with endothelial dysfunction, metabolic syndrome, increased mortality and recent studies showed a possible association with the increased risk of stroke. We performed a systematic review of studies evaluating the association between EAT and stroke. Eighty studies met the inclusion criteria and were consequently analyzed. The review had Five main findings. First, the increased epicardial fat thickness (EFT) may be associated with the stroke episode. Second, regardless of the imaging method (echocardiography, MRI, and CT) this association remains. Third, the association of metabolic syndrome and atrial fibrillation seems to increase the risk of stroke. Fourth, this systematic review was considered as low risk of bias. Despite being unable to establish a clear association between EAT and stroke, we have organized and assessed all the research papers on this topic, analyzing their limitations, suggesting improvements in future pieces of research and pointing out gaps in the literature. Furthermore, the mechanistic links between increased EAT and stroke incidence remains unclear, thus, further research is warranted.
AB - Epicardial adipose tissue (EAT) is correlated with endothelial dysfunction, metabolic syndrome, increased mortality and recent studies showed a possible association with the increased risk of stroke. We performed a systematic review of studies evaluating the association between EAT and stroke. Eighty studies met the inclusion criteria and were consequently analyzed. The review had Five main findings. First, the increased epicardial fat thickness (EFT) may be associated with the stroke episode. Second, regardless of the imaging method (echocardiography, MRI, and CT) this association remains. Third, the association of metabolic syndrome and atrial fibrillation seems to increase the risk of stroke. Fourth, this systematic review was considered as low risk of bias. Despite being unable to establish a clear association between EAT and stroke, we have organized and assessed all the research papers on this topic, analyzing their limitations, suggesting improvements in future pieces of research and pointing out gaps in the literature. Furthermore, the mechanistic links between increased EAT and stroke incidence remains unclear, thus, further research is warranted.
KW - atherosclerosis
KW - epicardial adipose tissue
KW - metabolic syndrome
KW - stroke
KW - systematic review
UR - https://www.scopus.com/pages/publications/85121227313
U2 - 10.3389/fcvm.2021.658445
DO - 10.3389/fcvm.2021.658445
M3 - Artículo de revisión
AN - SCOPUS:85121227313
SN - 2297-055X
VL - 8
JO - Frontiers in Cardiovascular Medicine
JF - Frontiers in Cardiovascular Medicine
M1 - 658445
ER -