E-cadherina: Expresión molecular en carcinomas de estómago de tipo difuso y tipo intestinal. Estudio realizado en Lima, Perú

Fernando Arévalo; E. Monge; D. Morales

E-cadherina: Expresión molecular en carcinomas de estómago de tipo difuso y tipo intestinal. Estudio realizado en Lima, Perú

Translated title of the contribution: E-cadherin molecular expresion in the diffuse and intestinal types of gastric adenocarcinoma: A report from Lima, Peru

Fernando Arévalo
, E. Monge
, D. Morales

Universidad Nacional Mayor de San Marcos

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: signet ring carcinoma of the stomach is well known to be more aggressive and infiltrating than adenocarcinoma. Different studies have proposed that signet ring cell carcinoma would be more infiltrating because of the lost of E-cadherin expression, this cadherin is a class of protein cell membrane protein which plays an important role in cell-adhesion. Methods: we carried out a transversal comparative study, in order to measure the E-cadherin expression in 10 cases of signet ring cell and in 10 cases of adenocarcinoma, with help of immunohistochemistry. Results: we found a bigger expression of E-cadherin in adenocarcinomas (100%) than signet ring cell carcinoma (40%), this difference was significative using Fisher test (p = 0,011). The lost of E-cadherine would explain the bigger infiltrating capacity in comparison to adenocarcinoma.

Translated title of the contribution	E-cadherin molecular expresion in the diffuse and intestinal types of gastric adenocarcinoma: A report from Lima, Peru
Original language	Spanish
Pages (from-to)	325-329
Number of pages	5
Journal	Revista Espanola de Enfermedades Digestivas
Volume	99
Issue number	6
State	Published - Jun 2007
Externally published	Yes

Cite this

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title = "E-cadherina: Expresi{\'o}n molecular en carcinomas de est{\'o}mago de tipo difuso y tipo intestinal. Estudio realizado en Lima, Per{\'u}",

abstract = "Objective: signet ring carcinoma of the stomach is well known to be more aggressive and infiltrating than adenocarcinoma. Different studies have proposed that signet ring cell carcinoma would be more infiltrating because of the lost of E-cadherin expression, this cadherin is a class of protein cell membrane protein which plays an important role in cell-adhesion. Methods: we carried out a transversal comparative study, in order to measure the E-cadherin expression in 10 cases of signet ring cell and in 10 cases of adenocarcinoma, with help of immunohistochemistry. Results: we found a bigger expression of E-cadherin in adenocarcinomas (100\%) than signet ring cell carcinoma (40\%), this difference was significative using Fisher test (p = 0,011). The lost of E-cadherine would explain the bigger infiltrating capacity in comparison to adenocarcinoma.",

keywords = "E-cadherine, Gastric adenocarcinoma, Gastric signet ring cell carcinoma",

author = "Fernando Ar{\'e}valo and E. Monge and D. Morales",

year = "2007",

month = jun,

language = "Espa{\~n}ol",

volume = "99",

pages = "325--329",

journal = "Revista Espanola de Enfermedades Digestivas",

issn = "1130-0108",

publisher = "ARAN Ediciones S.L",

number = "6",

}

TY - JOUR

T1 - E-cadherina

T2 - Expresión molecular en carcinomas de estómago de tipo difuso y tipo intestinal. Estudio realizado en Lima, Perú

AU - Arévalo, Fernando

AU - Monge, E.

AU - Morales, D.

PY - 2007/6

Y1 - 2007/6

N2 - Objective: signet ring carcinoma of the stomach is well known to be more aggressive and infiltrating than adenocarcinoma. Different studies have proposed that signet ring cell carcinoma would be more infiltrating because of the lost of E-cadherin expression, this cadherin is a class of protein cell membrane protein which plays an important role in cell-adhesion. Methods: we carried out a transversal comparative study, in order to measure the E-cadherin expression in 10 cases of signet ring cell and in 10 cases of adenocarcinoma, with help of immunohistochemistry. Results: we found a bigger expression of E-cadherin in adenocarcinomas (100%) than signet ring cell carcinoma (40%), this difference was significative using Fisher test (p = 0,011). The lost of E-cadherine would explain the bigger infiltrating capacity in comparison to adenocarcinoma.

AB - Objective: signet ring carcinoma of the stomach is well known to be more aggressive and infiltrating than adenocarcinoma. Different studies have proposed that signet ring cell carcinoma would be more infiltrating because of the lost of E-cadherin expression, this cadherin is a class of protein cell membrane protein which plays an important role in cell-adhesion. Methods: we carried out a transversal comparative study, in order to measure the E-cadherin expression in 10 cases of signet ring cell and in 10 cases of adenocarcinoma, with help of immunohistochemistry. Results: we found a bigger expression of E-cadherin in adenocarcinomas (100%) than signet ring cell carcinoma (40%), this difference was significative using Fisher test (p = 0,011). The lost of E-cadherine would explain the bigger infiltrating capacity in comparison to adenocarcinoma.

KW - E-cadherine

KW - Gastric adenocarcinoma

KW - Gastric signet ring cell carcinoma

UR - https://www.scopus.com/pages/publications/35848933006

M3 - Artículo

C2 - 17883295

AN - SCOPUS:35848933006

SN - 1130-0108

VL - 99

SP - 325

EP - 329

JO - Revista Espanola de Enfermedades Digestivas

JF - Revista Espanola de Enfermedades Digestivas

IS - 6

ER -

E-cadherina: Expresión molecular en carcinomas de estómago de tipo difuso y tipo intestinal. Estudio realizado en Lima, Perú

Abstract

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