Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study

Juan C. Gómez de la Torre; José Alonso Cáceres-Delaguila; Cecilia Muro-Rojo; Nathalia De La Cruz-Escurra; Cesar Copaja-Corzo; Miguel Hueda-Zavaleta; Daniella Arenas Siles; Vicente A. Benites-Zapata

doi:10.3390/tropicalmed7050066

Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study

Juan C. Gómez de la Torre
, José Alonso Cáceres-Delaguila
, Cecilia Muro-Rojo
, Nathalia De La Cruz-Escurra
, Cesar Copaja-Corzo
, Miguel Hueda-Zavaleta
, Daniella Arenas Siles
, Vicente A. Benites-Zapata

Clinical Laboratory Roe
Universidad Privada de Tacna
Hospital III Daniel Alcides Carrión-Essalud Tacna
Universidad Científica del Sur
obtuvo un doctorado en la de Maryland y realizó un postdoctorado de la Universidad de Toronto. Es docente-investigador en la Universidad San Ignacio de Loyola

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Insufficient data have been reported about the effect of the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) on the humoral response through time in healthcare workers (HCW). This retro-spective cohort studied the information of 252 HCW from a private laboratory, comparing the antibody-mediated response provoked by BBIBP-CorV between HCW previously infected with SARS-CoV-2 (PI) and not previously infected (NPI), employing the Elecsys® anti-SARS-CoV-2 S and the cPass™ SARS-CoV-2 Neutralization Antibody Detection kit at intervals of 21, 90, and 180 days after vaccination. The presence of neutralizing antibodies in HCW 21 days after full vaccination was 100% in PI and 91.60% in NPI. We observed a progressive decrease in antibody levels over time in both groups. Comparing HCW PI with NPI, PI had a 10.9, 14.3, and 8.6-fold higher antibody titer with the Elecsys® anti-SARS-CoV-2 S at 21 (p < 0.001), 90 (p< 0.001) and 180 days (p < 0.001) respectively, compared to NPI. Using the percent of signal inhibition (PSI) of the antibody neutralization cPass™, HCW PI showed a level of 1.3, 2.0, and 3.1 times more antibodies, at 21 (p < 0.001), 90 (p < 0.001), and 180 days (p < 0.001) respectively, compared to NPI. We determined a progressive decrease in humoral immunity over time, particularly higher in those NPI.

Original language	English
Article number	66
Journal	Tropical Medicine and Infectious Disease
Volume	7
Issue number	5
DOIs	https://doi.org/10.3390/tropicalmed7050066
State	Published - May 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BBIBP-CorV
COVID-19
SARS-CoV-2 vaccination
healthcare workers
immunoassay
neutralizing antibody

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10.3390/tropicalmed7050066

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Gómez de la Torre, J. C., Cáceres-Delaguila, J. A., Muro-Rojo, C., De La Cruz-Escurra, N., Copaja-Corzo, C., Hueda-Zavaleta, M., Siles, D. A., & Benites-Zapata, V. A. (2022). Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study. Tropical Medicine and Infectious Disease, 7(5), Article 66. https://doi.org/10.3390/tropicalmed7050066

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title = "Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study",

abstract = "Insufficient data have been reported about the effect of the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) on the humoral response through time in healthcare workers (HCW). This retro-spective cohort studied the information of 252 HCW from a private laboratory, comparing the antibody-mediated response provoked by BBIBP-CorV between HCW previously infected with SARS-CoV-2 (PI) and not previously infected (NPI), employing the Elecsys{\textregistered} anti-SARS-CoV-2 S and the cPass{\texttrademark} SARS-CoV-2 Neutralization Antibody Detection kit at intervals of 21, 90, and 180 days after vaccination. The presence of neutralizing antibodies in HCW 21 days after full vaccination was 100\% in PI and 91.60\% in NPI. We observed a progressive decrease in antibody levels over time in both groups. Comparing HCW PI with NPI, PI had a 10.9, 14.3, and 8.6-fold higher antibody titer with the Elecsys{\textregistered} anti-SARS-CoV-2 S at 21 (p < 0.001), 90 (p< 0.001) and 180 days (p < 0.001) respectively, compared to NPI. Using the percent of signal inhibition (PSI) of the antibody neutralization cPass{\texttrademark}, HCW PI showed a level of 1.3, 2.0, and 3.1 times more antibodies, at 21 (p < 0.001), 90 (p < 0.001), and 180 days (p < 0.001) respectively, compared to NPI. We determined a progressive decrease in humoral immunity over time, particularly higher in those NPI.",

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author = "\{G{\'o}mez de la Torre\}, \{Juan C.\} and C{\'a}ceres-Delaguila, \{Jos{\'e} Alonso\} and Cecilia Muro-Rojo and \{De La Cruz-Escurra\}, Nathalia and Cesar Copaja-Corzo and Miguel Hueda-Zavaleta and Siles, \{Daniella Arenas\} and Benites-Zapata, \{Vicente A.\}",

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Gómez de la Torre, JC, Cáceres-Delaguila, JA, Muro-Rojo, C, De La Cruz-Escurra, N, Copaja-Corzo, C, Hueda-Zavaleta, M, Siles, DA & Benites-Zapata, VA 2022, 'Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study', Tropical Medicine and Infectious Disease, vol. 7, no. 5, 66. https://doi.org/10.3390/tropicalmed7050066

TY - JOUR

T1 - Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers

T2 - A Cohort Study

AU - Gómez de la Torre, Juan C.

AU - Cáceres-Delaguila, José Alonso

AU - Muro-Rojo, Cecilia

AU - De La Cruz-Escurra, Nathalia

AU - Copaja-Corzo, Cesar

AU - Hueda-Zavaleta, Miguel

AU - Siles, Daniella Arenas

AU - Benites-Zapata, Vicente A.

PY - 2022/5

Y1 - 2022/5

N2 - Insufficient data have been reported about the effect of the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) on the humoral response through time in healthcare workers (HCW). This retro-spective cohort studied the information of 252 HCW from a private laboratory, comparing the antibody-mediated response provoked by BBIBP-CorV between HCW previously infected with SARS-CoV-2 (PI) and not previously infected (NPI), employing the Elecsys® anti-SARS-CoV-2 S and the cPass™ SARS-CoV-2 Neutralization Antibody Detection kit at intervals of 21, 90, and 180 days after vaccination. The presence of neutralizing antibodies in HCW 21 days after full vaccination was 100% in PI and 91.60% in NPI. We observed a progressive decrease in antibody levels over time in both groups. Comparing HCW PI with NPI, PI had a 10.9, 14.3, and 8.6-fold higher antibody titer with the Elecsys® anti-SARS-CoV-2 S at 21 (p < 0.001), 90 (p< 0.001) and 180 days (p < 0.001) respectively, compared to NPI. Using the percent of signal inhibition (PSI) of the antibody neutralization cPass™, HCW PI showed a level of 1.3, 2.0, and 3.1 times more antibodies, at 21 (p < 0.001), 90 (p < 0.001), and 180 days (p < 0.001) respectively, compared to NPI. We determined a progressive decrease in humoral immunity over time, particularly higher in those NPI.

AB - Insufficient data have been reported about the effect of the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) on the humoral response through time in healthcare workers (HCW). This retro-spective cohort studied the information of 252 HCW from a private laboratory, comparing the antibody-mediated response provoked by BBIBP-CorV between HCW previously infected with SARS-CoV-2 (PI) and not previously infected (NPI), employing the Elecsys® anti-SARS-CoV-2 S and the cPass™ SARS-CoV-2 Neutralization Antibody Detection kit at intervals of 21, 90, and 180 days after vaccination. The presence of neutralizing antibodies in HCW 21 days after full vaccination was 100% in PI and 91.60% in NPI. We observed a progressive decrease in antibody levels over time in both groups. Comparing HCW PI with NPI, PI had a 10.9, 14.3, and 8.6-fold higher antibody titer with the Elecsys® anti-SARS-CoV-2 S at 21 (p < 0.001), 90 (p< 0.001) and 180 days (p < 0.001) respectively, compared to NPI. Using the percent of signal inhibition (PSI) of the antibody neutralization cPass™, HCW PI showed a level of 1.3, 2.0, and 3.1 times more antibodies, at 21 (p < 0.001), 90 (p < 0.001), and 180 days (p < 0.001) respectively, compared to NPI. We determined a progressive decrease in humoral immunity over time, particularly higher in those NPI.

KW - BBIBP-CorV

KW - COVID-19

KW - SARS-CoV-2 vaccination

KW - healthcare workers

KW - immunoassay

KW - neutralizing antibody

UR - https://www.scopus.com/pages/publications/85129521326

U2 - 10.3390/tropicalmed7050066

DO - 10.3390/tropicalmed7050066

M3 - Artículo

AN - SCOPUS:85129521326

SN - 2414-6366

VL - 7

JO - Tropical Medicine and Infectious Disease

JF - Tropical Medicine and Infectious Disease

IS - 5

M1 - 66

ER -

Humoral Immune Response Induced by the BBIBP-CorV Vaccine (Sinopharm) in Healthcare Workers: A Cohort Study

Abstract

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Keywords

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