Lipid accumulation product and visceral adiposity index in women with and without polycystic ovary syndrome: a systematic review and meta-analysis

Juan R. Ulloque-Badaracco; Enrique A. Hernandez-Bustamante; Juan C. Cabrera-Guzmán; Jose E. Delgado-Raygada; Giuseppe Dotto-Vasquez; Gian F. Maldonado-Basurto; Alberto A. Figueroa-Larragán; Katherin Z. Trujillo-Jurado; Gustavo Evaristo-Ballmann; Aldo Flores-Gavino; Percy Herrera-Añazco; Vicente A. Benites-Zapata

doi:10.1177/20420188251397203

Lipid accumulation product and visceral adiposity index in women with and without polycystic ovary syndrome: a systematic review and meta-analysis

Juan R. Ulloque-Badaracco
, Enrique A. Hernandez-Bustamante
, Juan C. Cabrera-Guzmán
, Jose E. Delgado-Raygada
, Giuseppe Dotto-Vasquez
, Gian F. Maldonado-Basurto
, Alberto A. Figueroa-Larragán
, Katherin Z. Trujillo-Jurado
, Gustavo Evaristo-Ballmann
, Aldo Flores-Gavino
, Percy Herrera-Añazco
, Vicente A. Benites-Zapata

Universidad Peruana de Ciencias Aplicadas
obtuvo un doctorado en la de Maryland y realizó un postdoctorado de la Universidad de Toronto. Es docente-investigador en la Universidad San Ignacio de Loyola
Universidad Nacional de Trujillo
Universidad Nacional Federico Villarreal
Universidad Científica del Sur

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Polycystic ovary syndrome (PCOS) is a chronic, heterogeneous and prevalent endocrine-metabolic condition. Objectives: This study aims to synthesize the available evidence on the comparison of lipid accumulation product (LAP) and visceral adiposity index (VAI) in women with and without PCOS. Design: Systematic review and meta-analysis. Data sources and methods: A systematic search was executed across five electronic databases. Continuous variables were assessed using the standardized mean difference (SMD) and its 95% confidence interval (CI). Results: A total of 46 studies were included (n = 12,442). PCOS patients have higher values of LAP (n = 10,658; SMD: 0.65; 95% CI: 0.47–0.83, p < 0.05; I² = 93.65%) and VAI (n = 7930; SMD: 0.53; 95% CI: 0.21–0.85; p < 0.05; I² = 97.24%) compared to those without the syndrome. Conclusion: Women with PCOS show significantly higher VAI and LAP values than those without this syndrome.

Original language	English
Journal	Therapeutic Advances in Endocrinology and Metabolism
Volume	16
DOIs	https://doi.org/10.1177/20420188251397203
State	Published - 1 Jan 2025
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adiposity
lipid accumulation product
meta-analysis
polycystic ovary syndrome
systematic review
visceral adiposity index

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10.1177/20420188251397203

Cite this

Ulloque-Badaracco, J. R., Hernandez-Bustamante, E. A., Cabrera-Guzmán, J. C., Delgado-Raygada, J. E., Dotto-Vasquez, G., Maldonado-Basurto, G. F., Figueroa-Larragán, A. A., Trujillo-Jurado, K. Z., Evaristo-Ballmann, G., Flores-Gavino, A., Herrera-Añazco, P., & Benites-Zapata, V. A. (2025). Lipid accumulation product and visceral adiposity index in women with and without polycystic ovary syndrome: a systematic review and meta-analysis. Therapeutic Advances in Endocrinology and Metabolism, 16. https://doi.org/10.1177/20420188251397203

@article{9e2426db877c41cc8f70522a280ce21e,

title = "Lipid accumulation product and visceral adiposity index in women with and without polycystic ovary syndrome: a systematic review and meta-analysis",

abstract = "Background: Polycystic ovary syndrome (PCOS) is a chronic, heterogeneous and prevalent endocrine-metabolic condition. Objectives: This study aims to synthesize the available evidence on the comparison of lipid accumulation product (LAP) and visceral adiposity index (VAI) in women with and without PCOS. Design: Systematic review and meta-analysis. Data sources and methods: A systematic search was executed across five electronic databases. Continuous variables were assessed using the standardized mean difference (SMD) and its 95\% confidence interval (CI). Results: A total of 46 studies were included (n = 12,442). PCOS patients have higher values of LAP (n = 10,658; SMD: 0.65; 95\% CI: 0.47–0.83, p < 0.05; I2 = 93.65\%) and VAI (n = 7930; SMD: 0.53; 95\% CI: 0.21–0.85; p < 0.05; I2 = 97.24\%) compared to those without the syndrome. Conclusion: Women with PCOS show significantly higher VAI and LAP values than those without this syndrome.",

keywords = "adiposity, lipid accumulation product, meta-analysis, polycystic ovary syndrome, systematic review, visceral adiposity index",

author = "Ulloque-Badaracco, \{Juan R.\} and Hernandez-Bustamante, \{Enrique A.\} and Cabrera-Guzm{\'a}n, \{Juan C.\} and Delgado-Raygada, \{Jose E.\} and Giuseppe Dotto-Vasquez and Maldonado-Basurto, \{Gian F.\} and Figueroa-Larrag{\'a}n, \{Alberto A.\} and Trujillo-Jurado, \{Katherin Z.\} and Gustavo Evaristo-Ballmann and Aldo Flores-Gavino and Percy Herrera-A{\~n}azco and Benites-Zapata, \{Vicente A.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).",

year = "2025",

month = jan,

day = "1",

doi = "10.1177/20420188251397203",

language = "Ingl{\'e}s",

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journal = "Therapeutic Advances in Endocrinology and Metabolism",

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Ulloque-Badaracco, JR, Hernandez-Bustamante, EA, Cabrera-Guzmán, JC, Delgado-Raygada, JE, Dotto-Vasquez, G, Maldonado-Basurto, GF, Figueroa-Larragán, AA, Trujillo-Jurado, KZ, Evaristo-Ballmann, G, Flores-Gavino, A, Herrera-Añazco, P & Benites-Zapata, VA 2025, 'Lipid accumulation product and visceral adiposity index in women with and without polycystic ovary syndrome: a systematic review and meta-analysis', Therapeutic Advances in Endocrinology and Metabolism, vol. 16. https://doi.org/10.1177/20420188251397203

Lipid accumulation product and visceral adiposity index in women with and without polycystic ovary syndrome: a systematic review and meta-analysis. / Ulloque-Badaracco, Juan R.; Hernandez-Bustamante, Enrique A.; Cabrera-Guzmán, Juan C. et al.
In: Therapeutic Advances in Endocrinology and Metabolism, Vol. 16, 01.01.2025.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Lipid accumulation product and visceral adiposity index in women with and without polycystic ovary syndrome

T2 - a systematic review and meta-analysis

AU - Ulloque-Badaracco, Juan R.

AU - Hernandez-Bustamante, Enrique A.

AU - Cabrera-Guzmán, Juan C.

AU - Delgado-Raygada, Jose E.

AU - Dotto-Vasquez, Giuseppe

AU - Maldonado-Basurto, Gian F.

AU - Figueroa-Larragán, Alberto A.

AU - Trujillo-Jurado, Katherin Z.

AU - Evaristo-Ballmann, Gustavo

AU - Flores-Gavino, Aldo

AU - Herrera-Añazco, Percy

AU - Benites-Zapata, Vicente A.

N1 - Publisher Copyright: © The Author(s), 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PY - 2025/1/1

Y1 - 2025/1/1

N2 - Background: Polycystic ovary syndrome (PCOS) is a chronic, heterogeneous and prevalent endocrine-metabolic condition. Objectives: This study aims to synthesize the available evidence on the comparison of lipid accumulation product (LAP) and visceral adiposity index (VAI) in women with and without PCOS. Design: Systematic review and meta-analysis. Data sources and methods: A systematic search was executed across five electronic databases. Continuous variables were assessed using the standardized mean difference (SMD) and its 95% confidence interval (CI). Results: A total of 46 studies were included (n = 12,442). PCOS patients have higher values of LAP (n = 10,658; SMD: 0.65; 95% CI: 0.47–0.83, p < 0.05; I2 = 93.65%) and VAI (n = 7930; SMD: 0.53; 95% CI: 0.21–0.85; p < 0.05; I2 = 97.24%) compared to those without the syndrome. Conclusion: Women with PCOS show significantly higher VAI and LAP values than those without this syndrome.

AB - Background: Polycystic ovary syndrome (PCOS) is a chronic, heterogeneous and prevalent endocrine-metabolic condition. Objectives: This study aims to synthesize the available evidence on the comparison of lipid accumulation product (LAP) and visceral adiposity index (VAI) in women with and without PCOS. Design: Systematic review and meta-analysis. Data sources and methods: A systematic search was executed across five electronic databases. Continuous variables were assessed using the standardized mean difference (SMD) and its 95% confidence interval (CI). Results: A total of 46 studies were included (n = 12,442). PCOS patients have higher values of LAP (n = 10,658; SMD: 0.65; 95% CI: 0.47–0.83, p < 0.05; I2 = 93.65%) and VAI (n = 7930; SMD: 0.53; 95% CI: 0.21–0.85; p < 0.05; I2 = 97.24%) compared to those without the syndrome. Conclusion: Women with PCOS show significantly higher VAI and LAP values than those without this syndrome.

KW - adiposity

KW - lipid accumulation product

KW - meta-analysis

KW - polycystic ovary syndrome

KW - systematic review

KW - visceral adiposity index

UR - https://www.scopus.com/pages/publications/105022596797

U2 - 10.1177/20420188251397203

DO - 10.1177/20420188251397203

M3 - Artículo

AN - SCOPUS:105022596797

SN - 2042-0188

VL - 16

JO - Therapeutic Advances in Endocrinology and Metabolism

JF - Therapeutic Advances in Endocrinology and Metabolism

ER -

Ulloque-Badaracco JR, Hernandez-Bustamante EA, Cabrera-Guzmán JC, Delgado-Raygada JE, Dotto-Vasquez G, Maldonado-Basurto GF et al. Lipid accumulation product and visceral adiposity index in women with and without polycystic ovary syndrome: a systematic review and meta-analysis. Therapeutic Advances in Endocrinology and Metabolism. 2025 Jan 1;16. doi: 10.1177/20420188251397203

Lipid accumulation product and visceral adiposity index in women with and without polycystic ovary syndrome: a systematic review and meta-analysis

Abstract

UN SDGs

Keywords

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