MnPS3 shows anticancer behaviour towards lung cancer cells

Naziah Mohamad Latiff; Nur Farhanah Rosli; Carmen C. Mayorga-Martinez; Katerina Szokolava; Zdenek Sofer; Adrian C. Fisher; Martin Pumera

doi:10.1016/j.flatc.2019.100134

MnPS₃ shows anticancer behaviour towards lung cancer cells

Naziah Mohamad Latiff
, Nur Farhanah Rosli
, Carmen C. Mayorga-Martinez
, Katerina Szokolava
, Zdenek Sofer
, Adrian C. Fisher
, Martin Pumera

Nanyang Technological University
University of Chemistry and Technology, Prague
University of Cambridge
Brno University of Technology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Here, we report the anticancer behaviour of MnPS₃ towards lung cancer A549 cells where approximately 50% of the cells remain viable upon a low dosage of MnPS₃ treatment. We found that MnPS₃ triggers A549 cells to generate reactive oxygen species and undergo apoptosis leading to cell death. These findings serve as a platform for introducing MnPS₃ in biomedical applications.

Original language	English
Article number	100134
Journal	FlatChem
Volume	18
DOIs	https://doi.org/10.1016/j.flatc.2019.100134
State	Published - Nov 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

A549 cells
Anticancer
Cytotoxicity
MnPS

Access to Document

10.1016/j.flatc.2019.100134

Cite this

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title = "MnPS3 shows anticancer behaviour towards lung cancer cells",

abstract = "Here, we report the anticancer behaviour of MnPS3 towards lung cancer A549 cells where approximately 50\% of the cells remain viable upon a low dosage of MnPS3 treatment. We found that MnPS3 triggers A549 cells to generate reactive oxygen species and undergo apoptosis leading to cell death. These findings serve as a platform for introducing MnPS3 in biomedical applications.",

keywords = "A549 cells, Anticancer, Cytotoxicity, MnPS",

author = "\{Mohamad Latiff\}, Naziah and Rosli, \{Nur Farhanah\} and Mayorga-Martinez, \{Carmen C.\} and Katerina Szokolava and Zdenek Sofer and Fisher, \{Adrian C.\} and Martin Pumera",

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AU - Mohamad Latiff, Naziah

AU - Rosli, Nur Farhanah

AU - Mayorga-Martinez, Carmen C.

AU - Szokolava, Katerina

AU - Sofer, Zdenek

AU - Fisher, Adrian C.

AU - Pumera, Martin

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Y1 - 2019/11

N2 - Here, we report the anticancer behaviour of MnPS3 towards lung cancer A549 cells where approximately 50% of the cells remain viable upon a low dosage of MnPS3 treatment. We found that MnPS3 triggers A549 cells to generate reactive oxygen species and undergo apoptosis leading to cell death. These findings serve as a platform for introducing MnPS3 in biomedical applications.

AB - Here, we report the anticancer behaviour of MnPS3 towards lung cancer A549 cells where approximately 50% of the cells remain viable upon a low dosage of MnPS3 treatment. We found that MnPS3 triggers A549 cells to generate reactive oxygen species and undergo apoptosis leading to cell death. These findings serve as a platform for introducing MnPS3 in biomedical applications.

KW - A549 cells

KW - Anticancer

KW - Cytotoxicity

KW - MnPS

UR - https://www.scopus.com/pages/publications/85073745346

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DO - 10.1016/j.flatc.2019.100134

M3 - Artículo

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