Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes

Kavya G. Sundar; Lanbo Z. Yang; Mary C. Cambou; Ivana R.S. Varella; Marineide G. Melo; Eddy R. Segura; Ângela P. Ziegler; Breno R. Santos; Karin Nielsen-Saines

doi:10.1097/INF.0000000000004562

Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes

Kavya G. Sundar
, Lanbo Z. Yang
, Mary C. Cambou
, Ivana R.S. Varella
, Marineide G. Melo
, Eddy R. Segura
, Ângela P. Ziegler
, Breno R. Santos
, Karin Nielsen-Saines

SUNY Downstate Health Sciences University
Tulane University
David Geffen School of Medicine at UCLA
University of California at Los Angeles
Hospital Nossa Senhora da Conceição
Universidad Científica del Sur

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

From January 2008 to December 2018, 1348 HIV-exposed infants were born in Porto Alegre, Brazil; 18.8% had adverse infant outcomes (AIO) including vertical transmission (1.9%), stillbirth/neonatal death (4.0%) and loss to follow-up before HIV diagnosis (12.9%). Timing of maternal HIV diagnosis was not associated with AIO but absent antiretroviral therapy use was. Lack of maternal antiretroviral therapy use is a significant risk factor for AIO.

Original language	English
Pages (from-to)	40-43
Number of pages	4
Journal	Pediatric Infectious Disease Journal
Volume	44
Issue number	1
DOIs	https://doi.org/10.1097/INF.0000000000004562
State	Published - 1 Jan 2025
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV in pregnancy
HIV vertical transmission
adverse infant outcomes
antiretroviral therapy in pregnancy
maternal HIV seroconversion

Access to Document

10.1097/INF.0000000000004562

Cite this

Sundar, K. G., Yang, L. Z., Cambou, M. C., Varella, I. R. S., Melo, M. G., Segura, E. R., Ziegler, Â. P., Santos, B. R., & Nielsen-Saines, K. (2025). Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes. Pediatric Infectious Disease Journal, 44(1), 40-43. https://doi.org/10.1097/INF.0000000000004562

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title = "Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes",

abstract = "From January 2008 to December 2018, 1348 HIV-exposed infants were born in Porto Alegre, Brazil; 18.8\% had adverse infant outcomes (AIO) including vertical transmission (1.9\%), stillbirth/neonatal death (4.0\%) and loss to follow-up before HIV diagnosis (12.9\%). Timing of maternal HIV diagnosis was not associated with AIO but absent antiretroviral therapy use was. Lack of maternal antiretroviral therapy use is a significant risk factor for AIO.",

keywords = "HIV in pregnancy, HIV vertical transmission, adverse infant outcomes, antiretroviral therapy in pregnancy, maternal HIV seroconversion",

author = "Sundar, \{Kavya G.\} and Yang, \{Lanbo Z.\} and Cambou, \{Mary C.\} and Varella, \{Ivana R.S.\} and Melo, \{Marineide G.\} and Segura, \{Eddy R.\} and Ziegler, \{{\^A}ngela P.\} and Santos, \{Breno R.\} and Karin Nielsen-Saines",

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doi = "10.1097/INF.0000000000004562",

language = "Ingl{\'e}s",

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Sundar, KG, Yang, LZ, Cambou, MC, Varella, IRS, Melo, MG, Segura, ER, Ziegler, ÂP, Santos, BR & Nielsen-Saines, K 2025, 'Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes', Pediatric Infectious Disease Journal, vol. 44, no. 1, pp. 40-43. https://doi.org/10.1097/INF.0000000000004562

Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes. / Sundar, Kavya G.; Yang, Lanbo Z.; Cambou, Mary C. et al.
In: Pediatric Infectious Disease Journal, Vol. 44, No. 1, 01.01.2025, p. 40-43.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes

AU - Sundar, Kavya G.

AU - Yang, Lanbo Z.

AU - Cambou, Mary C.

AU - Varella, Ivana R.S.

AU - Melo, Marineide G.

AU - Segura, Eddy R.

AU - Ziegler, Ângela P.

AU - Santos, Breno R.

AU - Nielsen-Saines, Karin

PY - 2025/1/1

Y1 - 2025/1/1

N2 - From January 2008 to December 2018, 1348 HIV-exposed infants were born in Porto Alegre, Brazil; 18.8% had adverse infant outcomes (AIO) including vertical transmission (1.9%), stillbirth/neonatal death (4.0%) and loss to follow-up before HIV diagnosis (12.9%). Timing of maternal HIV diagnosis was not associated with AIO but absent antiretroviral therapy use was. Lack of maternal antiretroviral therapy use is a significant risk factor for AIO.

AB - From January 2008 to December 2018, 1348 HIV-exposed infants were born in Porto Alegre, Brazil; 18.8% had adverse infant outcomes (AIO) including vertical transmission (1.9%), stillbirth/neonatal death (4.0%) and loss to follow-up before HIV diagnosis (12.9%). Timing of maternal HIV diagnosis was not associated with AIO but absent antiretroviral therapy use was. Lack of maternal antiretroviral therapy use is a significant risk factor for AIO.

KW - HIV in pregnancy

KW - HIV vertical transmission

KW - adverse infant outcomes

KW - antiretroviral therapy in pregnancy

KW - maternal HIV seroconversion

UR - https://www.scopus.com/pages/publications/85207156795

U2 - 10.1097/INF.0000000000004562

DO - 10.1097/INF.0000000000004562

M3 - Artículo

AN - SCOPUS:85207156795

SN - 0891-3668

VL - 44

SP - 40

EP - 43

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 1

ER -

Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes

Abstract

UN SDGs

Keywords

Access to Document

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