TY - JOUR
T1 - RENDIMIENTO DIAGNÓSTICO DE UN SISTEMA MOLECULAR DE USO EN EL PUNTO DE ATENCIÓN PAR A LA DETECCIÓN DE SARS-CoV-2 EN PERÚ
AU - Puyén, Zully M.
AU - Araujo-Castillo, Roger
AU - Giraldo, Jorge
AU - Gutierrez, Karina
AU - Rojas-Serrano, Nancy
N1 - Publisher Copyright:
© 2024, Revista Peruana de Medicina Experimental y Salud Pública.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - The present study assessed the diagnostic performance of the Xpert®Xpress SARS-CoV-2 test in comparison with the Charité protocol real-time RT PCR for the detection of SARS-CoV-2 in Peruvian patients. This was a diagnostic test study that included 100 nasal and pharyngeal swab samples. We obtained an overall concordance of 98.70% (95%CI: 92.98-99.97), with a kappa coefficient of 0.97 (95%CI: 0.86-1.00) and sensitivity and relative specificity rates of 100% and 96.15%, respectively. Additionally, the percentage of the area under the ROC curve was 98.08% in both cases, and an analytical specificity rate of 100% was obtained for the different respiratory viruses evaluated. In conclusion, the Xpert®Xpress SARS-CoV-2 test, by using nasal and pharyngeal swab samples, was highly sensitive and specific, and the kappa coefficient showed an excellent correlation when compared to the reference test.
AB - The present study assessed the diagnostic performance of the Xpert®Xpress SARS-CoV-2 test in comparison with the Charité protocol real-time RT PCR for the detection of SARS-CoV-2 in Peruvian patients. This was a diagnostic test study that included 100 nasal and pharyngeal swab samples. We obtained an overall concordance of 98.70% (95%CI: 92.98-99.97), with a kappa coefficient of 0.97 (95%CI: 0.86-1.00) and sensitivity and relative specificity rates of 100% and 96.15%, respectively. Additionally, the percentage of the area under the ROC curve was 98.08% in both cases, and an analytical specificity rate of 100% was obtained for the different respiratory viruses evaluated. In conclusion, the Xpert®Xpress SARS-CoV-2 test, by using nasal and pharyngeal swab samples, was highly sensitive and specific, and the kappa coefficient showed an excellent correlation when compared to the reference test.
KW - COVID-19
KW - Molecular Diagnostic Techniques
KW - PCR
KW - Peru (source: MeSH NLM)
KW - SARS-CoV-2
KW - Sensitivity and Specificity
UR - https://www.scopus.com/pages/publications/85194847445
U2 - 10.17843/rpmesp.2024.411.13046
DO - 10.17843/rpmesp.2024.411.13046
M3 - Artículo
C2 - 38808849
AN - SCOPUS:85194847445
SN - 1726-4634
VL - 41
SP - 76
EP - 82
JO - Revista Peruana de Medicina Experimental y Salud Publica
JF - Revista Peruana de Medicina Experimental y Salud Publica
IS - 1
ER -
