Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis

Farley E. Salazar-Valdivia; Valeria A. Valdez-Cornejo; Juan R. Ulloque-Badaracco; Enrique A. Hernandez-Bustamante; Esteban A. Alarcón-Braga; Melany D. Mosquera-Rojas; Diana P. Garrido-Matta; Percy Herrera-Añazco; Vicente A. Benites-Zapata; Adrian V. Hernandez

doi:10.3390/diagnostics13050843

Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis

Farley E. Salazar-Valdivia
, Valeria A. Valdez-Cornejo
, Juan R. Ulloque-Badaracco
, Enrique A. Hernandez-Bustamante
, Esteban A. Alarcón-Braga
, Melany D. Mosquera-Rojas
, Diana P. Garrido-Matta
, Percy Herrera-Añazco
, Vicente A. Benites-Zapata
, Adrian V. Hernandez

Universidad Peruana de Ciencias Aplicadas
Sociedad Científica de Estudiantes de Medicina de la Universidad Nacional de Trujillo
obtuvo un doctorado en la de Maryland y realizó un postdoctorado de la Universidad de Toronto. Es docente-investigador en la Universidad San Ignacio de Loyola
Universidad Privada San Juan Bautista
Universidad Privada del Norte
University of Connecticut

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

The systemic immune-inflammation index (SIII) is a marker studied in multiple types of urologic cancer. This systematic review evaluates the association between SIII values with overall survival (OS) and progression-free survival (PFS) in testicular cancer. We searched observational studies in five databases. The quantitative synthesis was performed using a random-effects model. The risk of bias was assessed using the Newcastle–Ottawa Scale (NOS). The only measure of the effect was the hazard ratio (HR). A sensitivity analysis was performed according to the risk of bias in the studies. There were 833 participants in a total of 6 cohorts. We found that high SIII values were associated with worse OS (HR = 3.28; 95% CI 1.3–8.9; p < 0.001; I² = 78) and PFS (HR = 3.9; 95% CI 2.53–6.02; p < 0.001; I² = 0). No indication of small study effects was found in the association between SIII values and OS (p = 0.5301). High SIII values were associated with worse OS and PFS. However, further primary studies are suggested to enhance the effect of this marker in different outcomes of testicular cancer patients.

Original language	English
Article number	843
Journal	Diagnostics
Volume	13
Issue number	5
DOIs	https://doi.org/10.3390/diagnostics13050843
State	Published - Mar 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

meta-analysis
overall survival
progression free survival
systemic immune-inflammation index
testicular cancer

Access to Document

10.3390/diagnostics13050843

Cite this

Salazar-Valdivia, F. E., Valdez-Cornejo, V. A., Ulloque-Badaracco, J. R., Hernandez-Bustamante, E. A., Alarcón-Braga, E. A., Mosquera-Rojas, M. D., Garrido-Matta, D. P., Herrera-Añazco, P., Benites-Zapata, V. A., & Hernandez, A. V. (2023). Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis. Diagnostics, 13(5), Article 843. https://doi.org/10.3390/diagnostics13050843

@article{fd1917e7a46d4d818b629708fe172c49,

title = "Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis",

abstract = "The systemic immune-inflammation index (SIII) is a marker studied in multiple types of urologic cancer. This systematic review evaluates the association between SIII values with overall survival (OS) and progression-free survival (PFS) in testicular cancer. We searched observational studies in five databases. The quantitative synthesis was performed using a random-effects model. The risk of bias was assessed using the Newcastle–Ottawa Scale (NOS). The only measure of the effect was the hazard ratio (HR). A sensitivity analysis was performed according to the risk of bias in the studies. There were 833 participants in a total of 6 cohorts. We found that high SIII values were associated with worse OS (HR = 3.28; 95\% CI 1.3–8.9; p < 0.001; I2 = 78) and PFS (HR = 3.9; 95\% CI 2.53–6.02; p < 0.001; I2 = 0). No indication of small study effects was found in the association between SIII values and OS (p = 0.5301). High SIII values were associated with worse OS and PFS. However, further primary studies are suggested to enhance the effect of this marker in different outcomes of testicular cancer patients.",

keywords = "meta-analysis, overall survival, progression free survival, systemic immune-inflammation index, testicular cancer",

author = "Salazar-Valdivia, \{Farley E.\} and Valdez-Cornejo, \{Valeria A.\} and Ulloque-Badaracco, \{Juan R.\} and Hernandez-Bustamante, \{Enrique A.\} and Alarc{\'o}n-Braga, \{Esteban A.\} and Mosquera-Rojas, \{Melany D.\} and Garrido-Matta, \{Diana P.\} and Percy Herrera-A{\~n}azco and Benites-Zapata, \{Vicente A.\} and Hernandez, \{Adrian V.\}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = mar,

doi = "10.3390/diagnostics13050843",

language = "Ingl{\'e}s",

volume = "13",

journal = "Diagnostics",

issn = "2075-4418",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "5",

}

Salazar-Valdivia, FE, Valdez-Cornejo, VA, Ulloque-Badaracco, JR, Hernandez-Bustamante, EA, Alarcón-Braga, EA, Mosquera-Rojas, MD, Garrido-Matta, DP, Herrera-Añazco, P, Benites-Zapata, VA & Hernandez, AV 2023, 'Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis', Diagnostics, vol. 13, no. 5, 843. https://doi.org/10.3390/diagnostics13050843

TY - JOUR

T1 - Systemic Immune-Inflammation Index and Mortality in Testicular Cancer

T2 - A Systematic Review and Meta-Analysis

AU - Salazar-Valdivia, Farley E.

AU - Valdez-Cornejo, Valeria A.

AU - Ulloque-Badaracco, Juan R.

AU - Hernandez-Bustamante, Enrique A.

AU - Alarcón-Braga, Esteban A.

AU - Mosquera-Rojas, Melany D.

AU - Garrido-Matta, Diana P.

AU - Herrera-Añazco, Percy

AU - Benites-Zapata, Vicente A.

AU - Hernandez, Adrian V.

PY - 2023/3

Y1 - 2023/3

N2 - The systemic immune-inflammation index (SIII) is a marker studied in multiple types of urologic cancer. This systematic review evaluates the association between SIII values with overall survival (OS) and progression-free survival (PFS) in testicular cancer. We searched observational studies in five databases. The quantitative synthesis was performed using a random-effects model. The risk of bias was assessed using the Newcastle–Ottawa Scale (NOS). The only measure of the effect was the hazard ratio (HR). A sensitivity analysis was performed according to the risk of bias in the studies. There were 833 participants in a total of 6 cohorts. We found that high SIII values were associated with worse OS (HR = 3.28; 95% CI 1.3–8.9; p < 0.001; I2 = 78) and PFS (HR = 3.9; 95% CI 2.53–6.02; p < 0.001; I2 = 0). No indication of small study effects was found in the association between SIII values and OS (p = 0.5301). High SIII values were associated with worse OS and PFS. However, further primary studies are suggested to enhance the effect of this marker in different outcomes of testicular cancer patients.

AB - The systemic immune-inflammation index (SIII) is a marker studied in multiple types of urologic cancer. This systematic review evaluates the association between SIII values with overall survival (OS) and progression-free survival (PFS) in testicular cancer. We searched observational studies in five databases. The quantitative synthesis was performed using a random-effects model. The risk of bias was assessed using the Newcastle–Ottawa Scale (NOS). The only measure of the effect was the hazard ratio (HR). A sensitivity analysis was performed according to the risk of bias in the studies. There were 833 participants in a total of 6 cohorts. We found that high SIII values were associated with worse OS (HR = 3.28; 95% CI 1.3–8.9; p < 0.001; I2 = 78) and PFS (HR = 3.9; 95% CI 2.53–6.02; p < 0.001; I2 = 0). No indication of small study effects was found in the association between SIII values and OS (p = 0.5301). High SIII values were associated with worse OS and PFS. However, further primary studies are suggested to enhance the effect of this marker in different outcomes of testicular cancer patients.

KW - meta-analysis

KW - overall survival

KW - progression free survival

KW - systemic immune-inflammation index

KW - testicular cancer

UR - https://www.scopus.com/pages/publications/85149755948

U2 - 10.3390/diagnostics13050843

DO - 10.3390/diagnostics13050843

M3 - Artículo de revisión

AN - SCOPUS:85149755948

SN - 2075-4418

VL - 13

JO - Diagnostics

JF - Diagnostics

IS - 5

M1 - 843

ER -

Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis

Abstract

UN SDGs

Keywords

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Studies from Universidad Peruana de Ciencias Aplicadas Add New Findings in the Area of Testicular Cancer (Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis)

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Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

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Studies from Universidad Peruana de Ciencias Aplicadas Add New Findings in the Area of Testicular Cancer (Systemic Immune-Inflammation Index and Mortality in Testicular Cancer: A Systematic Review and Meta-Analysis)

Cite this