The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

Giovanny Garavito; Stéphane Bertani; Miguel Quiliano; Alexis Valentin; Ignacio Aldana; Eric Deharo

doi:10.1590/S0074-02762012000600019

The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

Giovanny Garavito
, Stéphane Bertani
, Miguel Quiliano
, Alexis Valentin
, Ignacio Aldana
, Eric Deharo

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

Original language	English
Pages (from-to)	820-823
Number of pages	4
Journal	Memorias do Instituto Oswaldo Cruz
Volume	107
Issue number	6
DOIs	https://doi.org/10.1590/S0074-02762012000600019
State	Published - 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimalarials
Drug combination
Methylene blue

Access to Document

10.1590/S0074-02762012000600019

Cite this

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abstract = "The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.",

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T1 - The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

AU - Garavito, Giovanny

AU - Bertani, Stéphane

AU - Quiliano, Miguel

AU - Valentin, Alexis

AU - Aldana, Ignacio

AU - Deharo, Eric

PY - 2012

Y1 - 2012

N2 - The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

AB - The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

KW - Antimalarials

KW - Drug combination

KW - Methylene blue

UR - https://www.scopus.com/pages/publications/84867002414

U2 - 10.1590/S0074-02762012000600019

DO - 10.1590/S0074-02762012000600019

M3 - Artículo

C2 - 22990975

AN - SCOPUS:84867002414

SN - 0074-0276

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SP - 820

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JO - Memorias do Instituto Oswaldo Cruz

JF - Memorias do Instituto Oswaldo Cruz

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The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

Abstract

UN SDGs

Keywords

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