TY - JOUR
T1 - Epstein-Barr virus as a prognostic factor in de novo nodal diffuse large B-cell lymphoma
AU - Morales, Domingo
AU - Beltran, Brady
AU - De Mendoza, Fernando Hurtado
AU - Riva, Luis
AU - Yabar, Alejandro
AU - Quiñones, Pilar
AU - Butera, James N.
AU - Castillo, Jorge
PY - 2010/1
Y1 - 2010/1
N2 - Although the International Prognostic Index (IPI) score is a valuable prognostic tool in diffuse large B-cell lymphoma (DLBCL), other risk-stratifying factors may be of value. The aim of this study was to define the prognostic value of EBV expression in de novo nodal DLBCL. Seventy-four cases were selected between January 2002 and December 2007. Clinical data were reviewed and tissue samples were evaluated for expression of CD20, CD10, bcl-6, MUM1, and EBV-encoded RNA (EBER). Of 74 evaluated cases, 53 cases (72%) were of non-germinal center-like subtype and 11 cases (15%) were positive for EBER. In a univariate analysis of the 57 patients who received chemotherapy, factors associated with survival were EBV status, performance status, LDH level, and IPI score. Using a multivariate analysis, a prognostic model was developed using IPI score and EBV status, which showed statistical significance. Our study supports EBV status as a powerful prognostic factor in de novo nodal DLBCL. Prospective studies should be carried to validate this hypothesis.
AB - Although the International Prognostic Index (IPI) score is a valuable prognostic tool in diffuse large B-cell lymphoma (DLBCL), other risk-stratifying factors may be of value. The aim of this study was to define the prognostic value of EBV expression in de novo nodal DLBCL. Seventy-four cases were selected between January 2002 and December 2007. Clinical data were reviewed and tissue samples were evaluated for expression of CD20, CD10, bcl-6, MUM1, and EBV-encoded RNA (EBER). Of 74 evaluated cases, 53 cases (72%) were of non-germinal center-like subtype and 11 cases (15%) were positive for EBER. In a univariate analysis of the 57 patients who received chemotherapy, factors associated with survival were EBV status, performance status, LDH level, and IPI score. Using a multivariate analysis, a prognostic model was developed using IPI score and EBV status, which showed statistical significance. Our study supports EBV status as a powerful prognostic factor in de novo nodal DLBCL. Prospective studies should be carried to validate this hypothesis.
KW - CHOP
KW - Diffuse large B-cell lymphoma
KW - EBV
KW - Prognostic factors
UR - https://www.scopus.com/pages/publications/74949106451
U2 - 10.3109/10428190903308015
DO - 10.3109/10428190903308015
M3 - Artículo
C2 - 19860616
AN - SCOPUS:74949106451
SN - 1042-8194
VL - 51
SP - 66
EP - 72
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 1
ER -
