Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes

Kavya G. Sundar; Lanbo Z. Yang; Mary C. Cambou; Ivana R.S. Varella; Marineide G. Melo; Eddy R. Segura; Ângela P. Ziegler; Breno R. Santos; Karin Nielsen-Saines

doi:10.1097/INF.0000000000004562

Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes

Kavya G. Sundar
, Lanbo Z. Yang
, Mary C. Cambou
, Ivana R.S. Varella
, Marineide G. Melo
, Eddy R. Segura
, Ângela P. Ziegler
, Breno R. Santos
, Karin Nielsen-Saines

SUNY Downstate Health Sciences University
Tulane University
David Geffen School of Medicine at UCLA
University of California at Los Angeles
Hospital Nossa Senhora da Conceição
Universidad Científica del Sur

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2 Citas (Scopus)

Resumen

From January 2008 to December 2018, 1348 HIV-exposed infants were born in Porto Alegre, Brazil; 18.8% had adverse infant outcomes (AIO) including vertical transmission (1.9%), stillbirth/neonatal death (4.0%) and loss to follow-up before HIV diagnosis (12.9%). Timing of maternal HIV diagnosis was not associated with AIO but absent antiretroviral therapy use was. Lack of maternal antiretroviral therapy use is a significant risk factor for AIO.

Idioma original	Inglés
Páginas (desde-hasta)	40-43
Número de páginas	4
Publicación	Pediatric Infectious Disease Journal
Volumen	44
N.º	1
DOI	https://doi.org/10.1097/INF.0000000000004562
Estado	Publicada - 1 ene. 2025
Publicado de forma externa	Sí

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Sundar, K. G., Yang, L. Z., Cambou, M. C., Varella, I. R. S., Melo, M. G., Segura, E. R., Ziegler, Â. P., Santos, B. R., & Nielsen-Saines, K. (2025). Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes. Pediatric Infectious Disease Journal, 44(1), 40-43. https://doi.org/10.1097/INF.0000000000004562

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title = "Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes",

abstract = "From January 2008 to December 2018, 1348 HIV-exposed infants were born in Porto Alegre, Brazil; 18.8\% had adverse infant outcomes (AIO) including vertical transmission (1.9\%), stillbirth/neonatal death (4.0\%) and loss to follow-up before HIV diagnosis (12.9\%). Timing of maternal HIV diagnosis was not associated with AIO but absent antiretroviral therapy use was. Lack of maternal antiretroviral therapy use is a significant risk factor for AIO.",

keywords = "HIV in pregnancy, HIV vertical transmission, adverse infant outcomes, antiretroviral therapy in pregnancy, maternal HIV seroconversion",

author = "Sundar, \{Kavya G.\} and Yang, \{Lanbo Z.\} and Cambou, \{Mary C.\} and Varella, \{Ivana R.S.\} and Melo, \{Marineide G.\} and Segura, \{Eddy R.\} and Ziegler, \{{\^A}ngela P.\} and Santos, \{Breno R.\} and Karin Nielsen-Saines",

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doi = "10.1097/INF.0000000000004562",

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Sundar, KG, Yang, LZ, Cambou, MC, Varella, IRS, Melo, MG, Segura, ER, Ziegler, ÂP, Santos, BR & Nielsen-Saines, K 2025, 'Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes', Pediatric Infectious Disease Journal, vol. 44, n.º 1, pp. 40-43. https://doi.org/10.1097/INF.0000000000004562

Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes. / Sundar, Kavya G.; Yang, Lanbo Z.; Cambou, Mary C. et al.
En: Pediatric Infectious Disease Journal, Vol. 44, N.º 1, 01.01.2025, p. 40-43.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes

AU - Sundar, Kavya G.

AU - Yang, Lanbo Z.

AU - Cambou, Mary C.

AU - Varella, Ivana R.S.

AU - Melo, Marineide G.

AU - Segura, Eddy R.

AU - Ziegler, Ângela P.

AU - Santos, Breno R.

AU - Nielsen-Saines, Karin

PY - 2025/1/1

Y1 - 2025/1/1

N2 - From January 2008 to December 2018, 1348 HIV-exposed infants were born in Porto Alegre, Brazil; 18.8% had adverse infant outcomes (AIO) including vertical transmission (1.9%), stillbirth/neonatal death (4.0%) and loss to follow-up before HIV diagnosis (12.9%). Timing of maternal HIV diagnosis was not associated with AIO but absent antiretroviral therapy use was. Lack of maternal antiretroviral therapy use is a significant risk factor for AIO.

AB - From January 2008 to December 2018, 1348 HIV-exposed infants were born in Porto Alegre, Brazil; 18.8% had adverse infant outcomes (AIO) including vertical transmission (1.9%), stillbirth/neonatal death (4.0%) and loss to follow-up before HIV diagnosis (12.9%). Timing of maternal HIV diagnosis was not associated with AIO but absent antiretroviral therapy use was. Lack of maternal antiretroviral therapy use is a significant risk factor for AIO.

KW - HIV in pregnancy

KW - HIV vertical transmission

KW - adverse infant outcomes

KW - antiretroviral therapy in pregnancy

KW - maternal HIV seroconversion

UR - https://www.scopus.com/pages/publications/85207156795

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DO - 10.1097/INF.0000000000004562

M3 - Artículo

AN - SCOPUS:85207156795

SN - 0891-3668

VL - 44

SP - 40

EP - 43

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 1

ER -

Prompt Initiation of Maternal Antiretroviral Therapy After HIV Seroconversion in Pregnancy Effectively Prevents Vertical Transmission and Other Adverse Infant Outcomes

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