The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

Giovanny Garavito; Stéphane Bertani; Miguel Quiliano; Alexis Valentin; Ignacio Aldana; Eric Deharo

doi:10.1590/S0074-02762012000600019

The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

Giovanny Garavito
, Stéphane Bertani
, Miguel Quiliano
, Alexis Valentin
, Ignacio Aldana
, Eric Deharo

Universidad Nacional de Colombia
Université Paul Sabatier Toulouse III
Institut de recherche pour le développement
University of Navarra
CNRS

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16 Citas (Scopus)

Resumen

The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

Idioma original	Inglés
Páginas (desde-hasta)	820-823
Número de páginas	4
Publicación	Memorias do Instituto Oswaldo Cruz
Volumen	107
N.º	6
DOI	https://doi.org/10.1590/S0074-02762012000600019
Estado	Publicada - 2012
Publicado de forma externa	Sí

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title = "The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine",

abstract = "The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.",

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T1 - The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

AU - Garavito, Giovanny

AU - Bertani, Stéphane

AU - Quiliano, Miguel

AU - Valentin, Alexis

AU - Aldana, Ignacio

AU - Deharo, Eric

PY - 2012

Y1 - 2012

N2 - The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

AB - The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

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KW - Drug combination

KW - Methylene blue

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DO - 10.1590/S0074-02762012000600019

M3 - Artículo

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AN - SCOPUS:84867002414

SN - 0074-0276

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JO - Memorias do Instituto Oswaldo Cruz

JF - Memorias do Instituto Oswaldo Cruz

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The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

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