The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

Giovanny Garavito; Stéphane Bertani; Miguel Quiliano; Alexis Valentin; Ignacio Aldana; Eric Deharo

doi:10.1590/S0074-02762012000600019

The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

Giovanny Garavito, Stéphane Bertani, Miguel Quiliano, Alexis Valentin, Ignacio Aldana, Eric Deharo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

15 Citas (Scopus)

Resumen

The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

Idioma original	Inglés
Páginas (desde-hasta)	820-823
Número de páginas	4
Publicación	Memorias do Instituto Oswaldo Cruz
Volumen	107
N.º	6
DOI	https://doi.org/10.1590/S0074-02762012000600019
Estado	Publicada - 2012
Publicado de forma externa	Sí

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.1590/S0074-02762012000600019

Otros archivos y enlaces

Enlace a la publicación en Scopus

Citar esto

@article{35a704752c7f46b185e3cbd825723eb6,

title = "The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine",

abstract = "The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.",

keywords = "Antimalarials, Drug combination, Methylene blue",

author = "Giovanny Garavito and St{\'e}phane Bertani and Miguel Quiliano and Alexis Valentin and Ignacio Aldana and Eric Deharo",

year = "2012",

doi = "10.1590/S0074-02762012000600019",

language = "Ingl{\'e}s",

volume = "107",

pages = "820--823",

journal = "Memorias do Instituto Oswaldo Cruz",

issn = "0074-0276",

publisher = "Fundacao Oswaldo Cruz",

number = "6",

}

TY - JOUR

T1 - The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

AU - Garavito, Giovanny

AU - Bertani, Stéphane

AU - Quiliano, Miguel

AU - Valentin, Alexis

AU - Aldana, Ignacio

AU - Deharo, Eric

PY - 2012

Y1 - 2012

N2 - The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

AB - The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

KW - Antimalarials

KW - Drug combination

KW - Methylene blue

UR - https://www.scopus.com/pages/publications/84867002414

U2 - 10.1590/S0074-02762012000600019

DO - 10.1590/S0074-02762012000600019

M3 - Artículo

C2 - 22990975

AN - SCOPUS:84867002414

SN - 0074-0276

VL - 107

SP - 820

EP - 823

JO - Memorias do Instituto Oswaldo Cruz

JF - Memorias do Instituto Oswaldo Cruz

IS - 6

ER -

The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

Resumen

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto