TY - JOUR
T1 - Unidentified dengue serotypes in DENV positive samples and detection of other pathogens responsible for an acute febrile illness outbreak 2016 in Cajamarca, Peru
AU - Del Valle-Mendoza, Juana
AU - Vasquez-Achaya, Fernando
AU - Aguilar-Luis, Miguel Angel
AU - Martins-Luna, Johanna
AU - Bazán-Mayra, Jorge
AU - Zavaleta-Gavidia, Victor
AU - Silva-Caso, Wilmer
AU - Carrillo-Ng, Hugo
AU - Tarazona-Castro, Yordi
AU - Aquino-Ortega, Ronald
AU - Del Valle, Luis J.
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/10/6
Y1 - 2020/10/6
N2 - Objective: To describe the prevalence of dengue virus serotypes, as well as other viral and bacterial pathogens that cause acute febrile illness during an outbreak in Cajamarca in 2016. Results: Dengue virus (DENV) was the most frequent etiologic agent detected in 25.8% of samples (32/124), followed by Rickettsia spp. in 8.1% (10/124), Zika virus in 4.8% (6/124), Chikungunya virus 2.4% (3/124) and Bartonella bacilliformis 1.6% (2/124) cases. No positive cases were detected of Oropouche virus and Leptospira spp. DENV serotypes identification was only achieved in 23% of the total positive for DENV, two samples for DENV-2 and four samples for DENV-4. During the 2016 outbreak in Cajamarca-Peru, it was observed that in a large percentage of positive samples for DENV, the infecting serotype could not be determined by conventional detection assays. This represents a problem for the national surveillance system and for public health due to its epidemiological and clinical implications. Other viral and bacterial pathogens responsible for acute febrile syndrome were less frequently identified.
AB - Objective: To describe the prevalence of dengue virus serotypes, as well as other viral and bacterial pathogens that cause acute febrile illness during an outbreak in Cajamarca in 2016. Results: Dengue virus (DENV) was the most frequent etiologic agent detected in 25.8% of samples (32/124), followed by Rickettsia spp. in 8.1% (10/124), Zika virus in 4.8% (6/124), Chikungunya virus 2.4% (3/124) and Bartonella bacilliformis 1.6% (2/124) cases. No positive cases were detected of Oropouche virus and Leptospira spp. DENV serotypes identification was only achieved in 23% of the total positive for DENV, two samples for DENV-2 and four samples for DENV-4. During the 2016 outbreak in Cajamarca-Peru, it was observed that in a large percentage of positive samples for DENV, the infecting serotype could not be determined by conventional detection assays. This represents a problem for the national surveillance system and for public health due to its epidemiological and clinical implications. Other viral and bacterial pathogens responsible for acute febrile syndrome were less frequently identified.
KW - Arbovirus
KW - Chikungunya
KW - Dengue
KW - PCR
KW - Peru
KW - Zika
UR - https://www.scopus.com/pages/publications/85092399512
U2 - 10.1186/s13104-020-05318-5
DO - 10.1186/s13104-020-05318-5
M3 - Artículo
C2 - 33023645
AN - SCOPUS:85092399512
SN - 1756-0500
VL - 13
JO - BMC Research Notes
JF - BMC Research Notes
IS - 1
M1 - 467
ER -
